![]() ![]() ![]() Within this hypothetical frame, the released serotonin could also interact with trigeminovascular afferents to activate and/or facilitate the release of the neuropeptide at the level of the trigeminal ganglion. As a consequence, there is activation of sensory nerve endings at the level of hard vessels in the meninges, with release of pro-inflammatory peptides (e.g., substance P and CGRP). This process could activate the trigeminal nerve terminals that innervate vascular walls. The activation of serotonergic receptors located on the walls of large cerebral vessels would lead to abnormal vasodilatation and consequently increase transmural pressure. Hypothesis/theory: Acting on the serotonergic neurons of the raphe nuclei, the dysfunction of orexinergic neurons would lead to a higher release of serotonin. Our hypothesis is that in migraine a dysfunction of orexinergic projections on the median raphe (MR) nuclei, interfering with serotonergic regulation, may cause Non-Rapid Eye Movement parasomnias, such as somnambulism. These two systems are anatomically and functionally interconnected. The serotonergic and orexinergic systems are both involved in the regulation of sleep/wake cycle, and numerous studies show that both are involved in the migraine etiopathogenesis. Introduction: Sleep and migraine share a common pathophysiological substrate, although the underlying mechanisms are unknown. 11Department of Surgical and Biomedical Sciences, University of Perugia, Perugia, Italy.10Anatomy Department, Faculty of Medicine and Surgery, University of Malta, Msida, Malta.9Struttura Complessa di Farmacia, Azienda Ospedaliero-Universitaria, Ospedali Riuniti di Foggia, Foggia, Italy.8Department of Health Sciences, University “Magna Graecia”, Catanzaro, Italy.7Child Neuropsychiatry, Department of Psychology and Pedagogical Sciences, University of Palermo, Palermo, Italy.6Department of Clinical and Experimental Medicine, University of Foggia, Foggia, Italy.5Neuropathology Research, MidAtlantic Neonatology Associates (MANA) and Biomedical Research Institute of New Jersey (BRInj), Morristown, NJ, United States.4Neuroscience Research, MidAtlantic Neonatology Associates, Atlantic Health System, Morristown NJ, United States.3Neurodevelopmental Research Lab, Biomedical Research Institute of New Jersey (BRInj), Cedar Knolls NJ, United States.2Clinic of Child and Adolescent Neuropsychiatry, Center for Childhood Headache, Department of Mental Health, Physical and Preventive Medicine, University of Campania “Luigi Vanvitelli”, Naples, Italy.1Department of Experimental Medicine, University of Campania “Luigi Vanvitelli”, Naples, Italy. ![]() Michele Roccella 7 Lucia Parisi 7 Margherita Salerno 7 Anna Valenzano 6 Agata Maltese 7 Monica Salerno 6 Francesco Sessa 6 Giuseppe Davide Albano 6 Rosa Marotta 8 Ines Villano 1 Gabriella Marsala 9 Christian Zammit 10 Francesco Lavano 8 Marcellino Monda 1 Giuseppe Cibelli 6 Serena Marianna Lavano 8 Beatrice Gallai 11 Roberto Toraldo 2 Vincenzo Monda 1 Marco Carotenuto 2 Antonietta Messina 1† Ilaria Bitetti 2† Francesco Precenzano 2 Diego Iacono 3,4,5 Giovanni Messina 6* ![]()
0 Comments
Leave a Reply. |
AuthorWrite something about yourself. No need to be fancy, just an overview. ArchivesCategories |